The book, The Doctors Mayo is about the life of Dr. W. W. Mayo and the formation of the world famous Mayo Clinic. Beginning with William Worrall Mayo's life in England the reader is led through the young man's career in the United States which eventually led him to the frontier state of Minnesota.
Highlights of the book include his work with refugees during the Dakota War of 1862 and his encouragement of Minnesota-raised Sir Henry Wellcome, who went on to fame in the world of pharmacy.
Throughout the book the underlying theme is Dr. Mayo's education and his determination to keep current with the latest medical developments. A determination not only for himself but for his two sons and for other doctors with whom he associated.